A STUDY OF ANTICANCER OF METHANOLIC EXTRACT FRACTIONS OF SUMATRAN Ficus pruniformis, Ficus Cunia, Ficus variegate and Ficus lepicarpa ON MICE BY BONE MARROW METHOD

Adnan, Adek Z. and Muktar, M. Husni and Nisa, Ghina Husnul and lrawati, lrawati (2010) A STUDY OF ANTICANCER OF METHANOLIC EXTRACT FRACTIONS OF SUMATRAN Ficus pruniformis, Ficus Cunia, Ficus variegate and Ficus lepicarpa ON MICE BY BONE MARROW METHOD. Working Paper. Fakultas Farmasi. (Unpublished)

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Abstract

During a phytochemical survey along Anai river in Anai Valley, padangpanjang, West Sumatra., four trees locally known as "Loloi", "Buku", "First Ikan-ikan", Second Ikan- ikan" were found and their barks, leaves or fruits gave a (+) alkaloid or flavonoid test. Those plants were identified by Herbarium of Department of Biology, Andalas University as Ficus cunia Buch-Ham (Moraceae), Ficus variegata Bl, Ficus lepicarpa Bl, and Ficus pruniformis B1. (2,3,4,5,6,7,8). The anticancer tests were conducted based on the formation of micronuclei cells induced by cyclophosphamide in bone marrow of mice hind leg. The tested compound were hexane, chloroform and ethyl acetate fraction from flavonoid extract and hexane, neutral chlorofonn, and basic chloroform fraction from alkaloid ectract scheme. The tested compound were administered orally for 7 consecutive days with dose of 300 mg/kg. body weight to white male mice. The experimental animals were then treated inuaperitoneally with cyclophpsphamide at a dose of 50 mg/kg body weight. The results indicated that the number of micronuclei cells affected by the all tested compound in mice were smaller then of control group (55.55% ). The strong decreasing effect were showed by ethyl acetate fraction of flavonoid of fruit of Ficus pruniformis (22.89 %) and neural chloroform fraction of alkaloid of leaves of Ficus lepicarpa Bl (25.44 % ).

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