THE FUNCTION UTILIZATION OF GAMBIER (Uncaria gambier) AS THE HEPATOPROTECTOR

Edward, Zulkarnain (2009) THE FUNCTION UTILIZATION OF GAMBIER (Uncaria gambier) AS THE HEPATOPROTECTOR. Riset Kimia, 2 (2). ISSN 1978-628X

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Abstract

The aim of the research is to find out the effect of the hepatoprotector from gambier to some rats animal contaminated by carbon tetrachloride (CCl4). The research was done in Biochemistry laboratory Medical Faculty Andalas University Padang applied to 12 galur wistar rats species in about ± 2 months ages with 170-200 g weight, which are separated into 3 groups (clusters). They are cluster in negative control, in positive control (CCl4 2 mg/kg BB inductions), and treated cluster (CCl4 inductions and 10 mg/kg BB gambier given). Statistically analyzed the data by one way Anova test with 95% confidence of degree, the result of the research are pointed to the rate of MDA serum level which is 1.08 ± 0.12 nmol/mL for the cluster in negative control, 4.07 ± 0.45 nmol/mL for positive control cluster, and 3.28 ± 0.46 nmol/mL for treated cluster showed the significant differences between the 3 clusters. The rates of MDA lever level to the cluster in negative control is about 1.80 ± 0.30 nmol/mL, in positive control is about 4.55 ± 0.56 nmol/mL, and the treated cluster is about 3.92 ± 0.22 nmol/mL, from the 3 clusters above shows that there is only the positive control and the treated control has no meaning of purpose. It concluded that the CCl4 has the hepatotoxite effect with gambier could be functionated as the hepatoprotector. Key words : gambier, CCl4, hepatoprotector, MDA

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