Pengaruh Bacterial Vaginosis Terhadap Kadar Matrixmetalloproteinase-9 pada Kehamilan Aterm

Harianto, Herry and Sulaini , Pelsi and Erkadius, Erkadius (2010) Pengaruh Bacterial Vaginosis Terhadap Kadar Matrixmetalloproteinase-9 pada Kehamilan Aterm. Other thesis, Fakultas Kedokteran Unand .

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Abstract

Backround :Matrixmetalloproteinase-g (MMP-9) are members of the MMP group who allegedly had a role in extracellular matrix degradation. lncreased MMP-9 caused by infection, especially bacterial vaginosis (BV). in pregnant women it is very possible infections caused by bacterialvaginosis that may affect levels of rnatrixmeta lloproteinase-9. Objective : To assess the influence of BV on MMP-9 levels in term pregnancy. Location : Clinic of Obstetrics and Gynecology of Dr. M. Djamil Padang General Hospital. Design: Cross Sectional Study. Materials and methods : all samples meet the inclusion criteria conducted anamnesis includes name, age, address, parity, last menstrual periode (LMP) and then performed a physical examination, examination of vaginal swab using a sterile cotton stick and venous blood sampling as much as 3 cc for the examination of serum levels of MMP-9 with ELISA KlT. The data is processed and analyzed statistically. Results : The study was conducted on 33 cases of term pregnant women, from 33 cases obtained MMP-9 decreased with negative bacterial vaginosis as many as 16 people, and MMP-9 increased with positive bacterial vaginosis as much as 9 people. Conclusion : Bacterial vaginosis is proven increased the levels of matrixmetalloproteinase-9 on term preg nanoy.

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