RAHMADINI HARLYA, RAHMADINI HARLYA
(2014)
MIKROENKAPSULASI VERAPAMIL HIDROKLORIDA MENGGUNAKAN METODE KOASERVASI DENGAN PENYALUT ALBUMIN.
Other thesis, Universitas Andalas.
Abstract
ABSTRACT
An investigation of microencapsulation verapamil hydrochloride with albumin as coating agent by using coaservation method had been done. Comparison between verapamil hydrochloride and albumin to the formula I, II, III and IV were 2:0,5 ; 2:1: ; 2:1,5 and 2:2. The resulting microcapsules were evaluated include photomicroscopic, analysis spectroscopy of IR, particle size distribution, determination of verapamil hydrochloride in microcapsules, dissolution test in 0.1N HCl medium and the kinetics of its release. The results showed microcapsules photomicroscopic produced multinucleated irregular shaped. Particle size distribution of microcapsules was 66.65 μm - 733.816 μm. Determination of verapamil hydrochloride in the microcapsules were 52,8769 ± 4,132, 58,6274 ± 0,631, 67,0695 ± 1,044, and 67,0695 ± 1,044 respectively - participated in the formula I, II, III, and IV. Dissolution results showed that the greater amount of albumin used in coating gave the greater inhibition release of verapamil hydrochloride from the microcapsules. Model release kinetics of verapamil hydrochloride from the microcapsules followed the Langenbucher equation.
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