Repository Universitas Andalas

Studi Efek Antihipertensi Tumbuhan Tali Putri (Cassytha filiformis L.) pada Tikus Hipertensi Yang Diinduksi Prednison dan Garam

Yuliandra, Yori and Armenia, Armenia and Arifin , Helmi (2013) Studi Efek Antihipertensi Tumbuhan Tali Putri (Cassytha filiformis L.) pada Tikus Hipertensi Yang Diinduksi Prednison dan Garam. Prosiding Seminar Nasional Perkembangan Terkini Sains Farmasi dan Klinik 3 . pp. 264-270. ISSN 2339-2592

[img]
Preview
PDF - Published Version
Download (177Kb) | Preview

Abstract

A study of the antihypertensive effect of Cassytha filiformis L. defatted extract on the hypertensive rats has been carried out. The study was conducted on 30 male Sprague-Dawley rats induced by Prednisone-NaCl for 14 days to obtain hypertensive rats. All rats were anesthetized to perform direct blood pressure measurement and divided into control group, extract-treated groups (5, 10 and 20 mg/kg), and tempol group. Each rat received three repetitive doses administered intravenously in one hour interval. During each dose interval, the systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were measured. All cardiovascular data were presented as mean of percentage change ± SEM. The data were analyzed by three-way ANOVA and Tukey’s HSD. The significance level was taken at P<0.05. The study showed that the defatted extract of C. filiformis decreased SBP, DBP, MAP, and HR significantly. The extract at the dose of 5 mg/kg and tempol 100 mcmol/kg showed insignificant difference in lowering blood pressure. Keywords: cassytha filiformis, tali putri, antihypertensive, blood pressure, heart rate

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Unit atau Lembaga: Fakultas Farmasi
Depositing User: Mr Yori Yuliandra
Date Deposited: 10 Sep 2014 04:40
Last Modified: 15 Sep 2017 15:02
URI: http://repository.unand.ac.id/id/eprint/20782

Actions (login required)

View Item View Item