SUTIA, DEDI
(2014)
HUBUNGAN KADAR ALPHA SYNUCLEIN PLASMA
DENGAN PENYAKIT PARKINSON.
Other thesis, ANDALAS UNIVERSITY.
Abstract
THE ASSOCIATION BETWEEN PLASM ALPHA SYNUCLEIN LEVEL
AND PARKINSON’S DISEASE
Dedi Sutia, Meiti Frida, Basjiruddin Ahmad
Abstract
Background: Parkinson’s disease is a chronic progressive neurodegenerative
disorder. Its etiology still remains unclear. Clinical examination is still believed as
the main method to diagnose the disease. Currently, alpha synuclein has come to
be correlated to the Parkinson’s disease. Abnormal accumulation of alpha
synuclein is considered to be toxic to the dopaminergic neurons. The aim of this
study is to demonstrate the correlation between the plasm alpha synuclein and the
Parkinson’s disease.
Methods: It is a cross observational comparative study involving 49 patients of
the Parkinson’s disease treated at the Dr. M. Djamil Padang and other networking
hospitals, and the control group of 31 healthy people. It was conducted between
December 2013 and June 2014. The level of plasm alpha synuclein was examined
by ELISA. The SPSS was used to analyse the data.
Results: For the patient group, the mean of age is 60.10+ 7.94 years old; men is
29 (59.2%); the mean of plasm alpha synuclein level is 5.15+1.44 ng/ml and the
median for male patient is 5.26 (3.21-8.91) ng/ml. There is different between
plasm alpha synuclein level and the Parkinson’s disease (p=0,002). There is no
different between plasm alpha synuclein level and sex of the patient (p=0,189).
There is association between plasm alpha synuclein level and the Parkinson’s
disease (p=0,049). There is no association between plasm alpha synuclein level
and sex of the patient (p=0,110).
Conclusion: There is different between plasm alpha synuclein level and the
Parkinson’s disease, but there is no different between plasm alpha synuclein level
and sex of the patient. There is association between plasm alpha synuclein level
and the Parkinson’s disease, but there is no association between plasm alpha
synuclein level and sex of the patient.
Key words: Parkinson’s disease, alpha synuclein
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