Aldi, Yufri and Mahyudin, Mahyudin and Handayani , Dian
(2013)
UJI AKTIVITAS BEBERAPA SUBFRAKSI ETIL ASETAT DARI HERBA MENIRAN (Phyllanthus niruri Linn.) TERHADAP REAKSI HIPERSENSITIVITAS KUTAN
AKTIF.
Jurnal Sains dan Teknologi Farmasi, 18
(1).
pp. 17-27.
ISSN 1410-0177
Abstract
A study on the activity of some ethyl acetate subfraction of meniran herbs
(Phyllanthus niruri Linn.) on the cutaneous active hypersensitive reaction has been
conducted. The subfraction (1,2, and 3) were at the dose of 50 mg/Kg BW and 100 mg/Kg
BW dispersed with 1% tween 80: Chicken egg albumin at concentration 25% and 30% were
used as control, all of which were given for 10 days. The Hipersensitivity reaction was
observed at day 10
th
. Result Showed that subfraction 1,2, and 3 at doses 50 mg/Kg BW and
100 mg/Kg BW inhibited hypersensitivity, reaction significantly, the onset of blue skin bump
were best given by subfraction 3 (dose 100 mg/Kg BW), the diameter of blue skin bump were
best given by subfraction 2 (50 mg/Kg BW) and the intensity of the blue skin bump was besy
given by subfraction 2 (100 mh/Kg BW). In summary, the ethyl aceble subfraction of
meniron herbs (Phyllanthus niruri Linn.) showed an immunostimulan activity.
Keyword : Meniran Herbs, The cutaneous active hypersensitive reaction, blue skin bump,
immunostimulan
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