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Isolation and Protection Effects of Methyl Gallate from Surian Leaves (Toona sureni BL Merr) Against Atherosclerosis of Hypercholesterolemic Rat

Suhatri, Suhatri and Yanwirasti, Yanwirasti and Nasrul, Ellyza and Dachriyanus, Dachriyanus and Indrawan, Satriko and Marusin, Netty and TOBAT, SANUBARI RELA and Yuliandra , Yori (2016) Isolation and Protection Effects of Methyl Gallate from Surian Leaves (Toona sureni BL Merr) Against Atherosclerosis of Hypercholesterolemic Rat. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 7 (4). pp. 870-875. ISSN 0975-8585

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Abstract

A study on the protection effect of methyl gallate (MG) isolated from Toona sureni leaves against atherosclerosis has been carried out. Mice with high blood cholesterol level were obtained by feeding with high fat diet and inducing propyl thiouracil (PTU). Methyl gallate was administered orally at the doses of 5, 10, and 20 mg/kg. Histopathologic examination was conducted to measure the aortic wall thickness (AWT) and to observe any improvement of endothelial layer. The study showed that MG at doses of 5 and 10 mg/kg exhibited protection against the atherosclerosis indicated by its ability to prevent the thickening of aortic wall and damage of endothelial layer. This study concludes that methyl gallate isolated from Toona sureni leaves exhibits a protective effect against atherosclerosis in hypercholesterolemic mice.

Item Type: Article
Uncontrolled Keywords: methyl gallate; Toona sureni; aterosklerosis; aortic wall thickness; endothelial layer
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RC Internal medicine > Cardiology
Unit atau Lembaga: Fakultas MIPA > Biologi
Pascasarjana > Doktor > Fakultas MIPA > Biologi
Fakultas MIPA > Biologi
Depositing User: Mr Yori Yuliandra
Date Deposited: 15 Oct 2016 01:19
Last Modified: 15 Oct 2016 01:19
URI: http://repository.unand.ac.id/id/eprint/23768

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