DISTRIBUTION OF CELLS EXPRESSING FcRI, FcRII AND FcRIII IN THE RHAUMATOID SYNOVIUM

Darwin, Eryati (2010) DISTRIBUTION OF CELLS EXPRESSING FcRI, FcRII AND FcRIII IN THE RHAUMATOID SYNOVIUM. Majalah Kedokteran Andalas, 22 (1). ISSN 0126 – 2092

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Abstract

Rheumatoid Arthritis (RA) is characterized bt chronic inflammation, infiltration of cells, e.g. monocytes, lymphocytes and proliveration of connetive tissue. Fc receptor for IgG (FcR) on macrophage, granulocytes and lymphocytes have been shown to be important triggers of effector stimulating cells thorough these receptors. We have investigated the distribution of cells bearing FcR of 12 RA Synovium and three osteoarthrois (OA) from post operatif patients using monoclonal antibody CD14, CD64, CDw32 and CD16 on serila cryostat section by immunohistology staining methods. Cells densities and degree of lymphocytes infiltration were significan high in RA compared to OA. Frequencies of cells expressing FcRI, FcRII, and FcRIII were calculated as percentage of the monocytes/macrophages. They range from 18 – 61 with no significan difference between RA and OA, and there was no correlation with the degree of lymphocitic infiltration. We observed distinctive patterns for three Fc receptor, suggesting that there may be differential regulation and expression of these molecules on subpopulation which might be of functionla importance. Keywords : Rheumatoid Arthritis, Fc Receptors, monoclonal anti body

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