GAMBIER (UNCARIA GAMBIR/HUNTER ROXB) ADMINISTRATION IMPROVES LOCOMOTOR ACTIVITIES AND NEUROCOGNITIVE IMPAIRMENT IN ALZHEIMER’S MODEL FEMALE RAT

Ulya Uti Fasrini, - and Restu Susanti, - and Lipoeto, Nur Indrawaty (2017) GAMBIER (UNCARIA GAMBIR/HUNTER ROXB) ADMINISTRATION IMPROVES LOCOMOTOR ACTIVITIES AND NEUROCOGNITIVE IMPAIRMENT IN ALZHEIMER’S MODEL FEMALE RAT. GAMBIER (UNCARIA GAMBIR/HUNTER ROXB) ADMINISTRATION IMPROVES LOCOMOTOR ACTIVITIES AND NEUROCOGNITIVE IMPAIRMENT IN ALZHEIMER’S MODEL FEMALE RAT, 35 (1). pp. 17-23. ISSN 0216-6402

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Abstract

Introduction: Locomotor activity (LA) disturbance and neurocognitive impairment in Alzheimer’s disease (AD) mechanism was suggested through many ways; one of them is the induction of oxidative stress that corrupted hippocampus cortex. Aims: The aim of this study was to determine whether or not the administration of potent antioxidant gambier catechin (GDC) to AD model female rat improves locomotion (LA) and cognitive function (CF). Methods: This experimental research was carried out to 12-week-old 25 Sprague dawley AD model female rats with proven CF impairment. Subjects were divided into 5 groups; control negative (N) and positive (P), and catechin groups (AC1, AC2, and AC3), which treated with oral GDC, 20mg, 40mg, and 60mg/200gBW, respectively, for four weeks. LA (total arm entered) and spatial memory were measured before and after treatment using Y-maze based on spontaneous alternation of each groups. Results: There were significant alteration differences in AC2 and AC3 groups (69% and 2%) after 40mg and 60mg/299gBW treatment after 4 weeks. Discussion: 40mg and 60mg/200gBW oral GDC treatment for four weeks improves spatial memory function on AD model female rat, however no significant changes on locomotor activity. Keywords: Alzheimer, catechin, cognitive, gambier, locomotor, rat

Item Type:	Article
Subjects:	R Medicine > RZ Other systems of medicine
Unit atau Lembaga:	Kedokteran
Depositing User:	dr. Ulya Uti Fasrini -
Date Deposited:	09 Aug 2018 02:11
Last Modified:	09 Aug 2018 02:11
URI:	http://repository.unand.ac.id/id/eprint/24625

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