AKTIVITAS EKSTRAK ETANOL DAUN CONNARUS GRANDIS JACK. TERHADAP SISTIM SARAF PUSAT.

Armenia, Armenia and Wattimena, Wattimena (2010) AKTIVITAS EKSTRAK ETANOL DAUN CONNARUS GRANDIS JACK. TERHADAP SISTIM SARAF PUSAT. JUMPA JURNAL MATEMATIKA DAN PENGETAHUAN ALAM, 3 (1). ISSN 0853-0033

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Abstract

The central nervous system depressant activity of the ethanolic extract af Connarus grandis leaves has been evaluated by using the prolongrng sleeping time of barbiturat and anti convulsion methods. [n this study the ED50 of pentobarbital in mice was reduced by 10 mg/tg body weigh extract from 29.A6 to 23.18 m/kg.The extract prolonged the sleeping time of mice induced by several level doses of pentobarbital (p < 0.01) while the oncset of sleeping was not significantly affected (p>0.01). Connarus grandis leavese Kract was also protected mice from convulsion indued by 2 mgkg bw strychnine nitrate but not by 100 mdkg pentetrazol. The CPDstr 50 of 47.50 mdkg and the DPDstr 50 of K.1A m/kg. Thus, the ethanolic extract of Connants grandis leave acted upon the inhibitory nervous system mediatedby glycine.

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