METABOLIC ENGINEERING AND BIOSYNTHESIS OF INDOLE ALKALOID IN Catharantus roseus (L) G.DON

Syukur , Sumaryati (2010) METABOLIC ENGINEERING AND BIOSYNTHESIS OF INDOLE ALKALOID IN Catharantus roseus (L) G.DON. Jurnal Kimia Andalas, 7 (1). ISSN 0853-8018

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Abstract

Terpenoid indole alkaloids (TIAs) is the most important alkaloid for pharmaceutical interest. Catharantus roseus (L) G.Don (Apocynaceae) is the commercial source of three such alkaloids, which have pharmaceutical applications and intensively inversigated. Ajmalicine is used to improve cerebral circulation, and dimeric alkaloid vinblastine and vineristine are important anticancer drugs. The biosynthesis of these alkaloids has been described quite extensively. Elicitor-induced defense responses include the biosynthesis of secondary metabolites accumulation, gene expression, have been studying for their effect on alkaloid biosynthesis. The effects of environmental such as light and abiotik stress on alkaloid accumulation have also been studied.

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