Studi Penggunaan Metode Voltametri “Stripping” Anoda untuk Analisa Kualitatif dan Kuantitatif Senyawa Etinil Estradiol dalam Tablet Kontrasepsi Oral

Andayani , Regina and Satiadarma , Kosasih and Firman, Kurnia (2010) Studi Penggunaan Metode Voltametri “Stripping” Anoda untuk Analisa Kualitatif dan Kuantitatif Senyawa Etinil Estradiol dalam Tablet Kontrasepsi Oral. Jurnal Sains dan Teknologi Farmasi, 7 (1). ISSN 1410 – 0177

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Abstract

Analytical method for the determination of ethinyl estradiol in pure form and in solid pharmaceutical preparations by voltametric technique with a hanging mercury drop electrode had been developed. The analysis of ethinyl estradiol had been performed using differential pulse voltametry. A deposition stage at -500 mV had been applied prior to the analysis followed by an anodic stripping step. Ethinyl estradiol was analyzed in methanol and 0,1 M sodium carbonate buffer of pH 11,5 (1:1). The peak potensials (Ep) of ethinyl estradiol was -348,40 mV. The detection limit of ethinyl estradiol was 2,94 x 10-6 M. ethinyl estradiol in tablet preparations could be identified and assayed without separation. The recovery of ethinyl estradiol of 6 µg/ml in simulation tablet was 98.20 %. Keywords : ethinyl estradiol, voltametric, solid pharmaceutical preparations

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