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Uji Preklinis Virgin Cocounut Oil Terhadap Peningkatan Kadar Kolesterol Baik HDL, Penurunan Kadar Trigliselida, Profil Asam Lemak(C6-C18) dan Omega-3 Pada Serum Darah Tikus Putih (Mus musculus)

Syukur, Sumaryati and Dahlyanti, Rina and Sumanti, Titi and Murni, Yulia and Hidayat, Zoni and Arifin , Helmi and Purwati, Endang and Risfaheri, Risfaheri (2014) Uji Preklinis Virgin Cocounut Oil Terhadap Peningkatan Kadar Kolesterol Baik HDL, Penurunan Kadar Trigliselida, Profil Asam Lemak(C6-C18) dan Omega-3 Pada Serum Darah Tikus Putih (Mus musculus). Jurnal Riset Kimia . ISSN 1978-628X

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Abstract

The Virgin Coconut Oil (VCO) products have different qualities Arid con::nvcrsy effects of lipids metabolism. This research has been used one of VCO product that was produced by fermentation method using Lactobacillus sp. It has high amount of lauric acid (C12) up to 51 Sc, caprilic acid (C8) 8.9 %, capric acid (C10) 7 % include Orneea-3, 6 and 9, vitamins A, D. E. K and three kinds of phytohormone. The ratio of Omega-3 and 6 was very proportional, therefore it is important to investigate the Pre Clinic Test of animal experiment. Pre Clinic Test of dietary VCO as food supplement has been determined by using 40 mice’s, which divided into 4 groups. Feeding on egg yolk to Group I (negative control), Group II (positive control) increased cholesterol level. The others were Group III (egg yolk and VCO 2-4%) and group IV (egs yolk and VCO 4 %). It was determined the total of cholesterol, HDL at 10th 20" and 30th day treated by using the enzymatic rnethods. The dietary of VCO 2-4% resulted in significant increases in HDL levels from 32 % to 69 %. The dietary of VCO 4 °% for four weeks did not toxic to mice metabolism. Triglycerides level decreased 50% from 177 to 85 and similar resulted to cholesterol ratio. Feeding on VCO for 4 weeks, the SCFA and MCFA not detected in serum of mice. The LCFA (C16) palmitatc in significant decreased from 0.96 to 0,1%. The significant level of Omega-3 increased more than three times in serum of mice dietary VCO 2-4 % Keywords: Coconut Oil, Lactobacillus

Item Type: Article
Subjects: Q Science > QD Chemistry
Unit atau Lembaga: Fakultas MIPA > Kimia
Paca Sarjana > Doktor > Fakultas MIPA > Kimia
Fakultas MIPA > Kimia
Depositing User: ST Irwan Kurniawan
Date Deposited: 22 Jun 2010 07:38
Last Modified: 31 Aug 2015 02:28
URI: http://repository.unand.ac.id/id/eprint/2922

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