Efek Antiinflamasi Ekstrak Etanol Kunyit (Curcuma domestica Val.) Pada Tikus Putih Jantan Galur Wistar

Rustam, Erlina and Atmasari , Indah and Yanwirasti, Yanwirasti (2014) Efek Antiinflamasi Ekstrak Etanol Kunyit (Curcuma domestica Val.) Pada Tikus Putih Jantan Galur Wistar. Jurnal Sains dan Teknologi Farmasi, 12 (2). pp. 112-115. ISSN 1410-0177

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Abstract

An experimental study has been done in rats to verify the inflammatory activity of Curcuma domestica yal. ethanolic extract About 25 rats were grouped randomly into 5 groups of animals. The experiment was conducted in the following manners. As a control group (group X) were fed with 1 ml/100g body weight of 0.5% NaCMC suspension in 0.9% NaCl, another groups (A, B, C, and D) were fed with 1 ml/100g body weight of (100,250,500 and 1000) mg/kg body weight suspension of extract. One hour later, to induce the inflammatory, all rats were injected with 0.2 ml of 1 % caragen suspension intracutan. The antiinflammatory effect were evaluated by measuring the left hind paw volume with platysmometer. The assesment was done in each rats of all groups, 1, 2,3,4,5, and 6 hours alter inflammatory induction. The resuts showed that were significant difference between the effect of tumeric ethanol extract as anti inflammation in all dosages. The hight dose (1000 mg/kg) were can inhibit the inflammation 78,37% . On conclution of this research, the tumeric ethanolic extract heve anti inflammation effect. Key word : Antiinflamasi, Curcuma domestica YaL

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