A Kinetic Study on the Loss of Sulfamethoxazole in Honey Solutions

Lucida, Henny and Dahlan, Radjudin and Frengki, Hamzatil (2010) A Kinetic Study on the Loss of Sulfamethoxazole in Honey Solutions. Jurnal Sains dan Teknologi Farmasi, 9 (2). ISSN 1410 – 0177

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Abstract

A study on the kinetic of sulfamethoxazole in acetate buffer pH 3,6 containing 50% honey at various temperatures has been done. Sample were taken at time interval until the concentration of sulfamethoxazole remaining was constant. As control, a solution of sulfamethoxazole in buffer solution without honey was treated at similar conditions. The concentration of sulfamethoxazole remaining was determined speetrophotometrically by using Bratton-Marshall methode. Result showed that the decrease in the concentration of sulfamethoxazole in buffer solution containing 50% honey followed pseudo first order reversible kinetics with the forward rate constans of 0,0803; 0,1932; 0,2937/hr. the reserve rate constans of 0,0595; 0,1423; 0,2084/hr respectively at 60o, 70o, anda 80o C. Reaction followed the arrhenius equation with the Ea value of 20,5459 kcal/mole and 21,1272 keal/mole for the fordward and reverse reaction respectively. The self life of sulfamethoxazole in honey solution pH 3,6 at room temperature was 56,6769 hours.

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