Isolasi Senyawa Antimikroba dari Fraksi Semi Polar Ekstrak Metanol Limbah Kulit Batang Kayu Jati (Tectona Grandis F)

allen, Yohannes and Ningrum, Eka Verawati and Rustini, Rustini (2010) Isolasi Senyawa Antimikroba dari Fraksi Semi Polar Ekstrak Metanol Limbah Kulit Batang Kayu Jati (Tectona Grandis F). Jurnal Sains dan Teknologi Farmasi, 9 (2). ISSN 1410 – 0177

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Abstract

An antimicrobial component was successfully isolated from aethyl acetate fraction of Tectona Grandis Linn. F (Bark) which was guided by antimicrobial dilution method. Separation and purification were done by chromatoghrapic methods. The active compound namely EV-19-19 (35 mg, mp 230-232o C) showed antimicrobial activity against. Staphylococcus aureus ATCC 6538 (MIC 100 ppm), Staphylococcus epidermidis ATCC 12228 (MIC 50 ppm), Pseudomonas aerognusa ATCC 15442 (MIC 50 ppm), Eschericia coli ATCC 8739 (MIC 50 ppm) and Tricophyton mentagrophytes ATCC 543 (MIC 50 ppm). While the compound showed no activity against Candida albicans ATCC 1023. Based on the spectral data (ultraviolet, infrared) and cemical reactions, the compound was identified as steroidal compound. Keyword: Tectona Grandis Linn. F, antimicrobial, Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Pseudomonas aerognusa ATCC 15442, Eschericia coli ATCC 8739, Tricophyton mentagrophytes ATCC 543, Candida albicans ATCC 1023, methode ilusi.

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