Efek Rilmenidin Terhadap Tekanan Darah dan Laju Jantung pada Tikus Sprague-Dawley Terekspansi Volume Salin

arifin, Helmi and Armenia, Armenia and Johns, E.J and Munawar, A.S. and yusuf, A.P.M (2010) Efek Rilmenidin Terhadap Tekanan Darah dan Laju Jantung pada Tikus Sprague-Dawley Terekspansi Volume Salin. Jurnal Sains dan Teknologi Farmasi, 9 (2). ISSN 1410 – 0177

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Abstract

This experiment sets out to examine the effect of riloteatidin on blood pressure SBP. Diastole blood pressure SBP reduction and heart rate (HR) on aecute salin volume expansion Sprague-Dawley (SD) male rats. The animal were anaesthethised with a mixture of fluothane/O2 and thereafter unantained on chloralose urethame administrated I, v, via femoral vein. Changes in SBP, DBP, and HR were monitored using a grass transducter connected to lab VIEW data acquisition system on a Macintosh computer. Saline (0,9% w/v NaCl) was infused at 3ml/h and the experiment begun 2hr later. Following the collection of baseline data, bolus doses rilmenidine, 0, 100, 300, and 1000µg/kg body weight were administered 15 minutes before saline infusion was expanded, such the animal received 0,25% body weight min over 50 min. The data obtained was compared using 2 way ANOVA and was considered to be significant when P<0,05. The result showed that saline volume expansion on the SD rats reduced the lowering blood pressure and HR of rilmenidine. Keywords: Rilmenidin, Blood pressure, saline volume expansion

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