Peningkatan kelarutan Kuersetin Melalui pembentukan Kompeks Inklusi dengan β-Siklodekstrin

Syofyan, Syofyan and Lucida , Henny and bachtiar, Amri (2008) Peningkatan kelarutan Kuersetin Melalui pembentukan Kompeks Inklusi dengan β-Siklodekstrin. Jurnal Sains dan Teknologi Farmasi, 13 (2). ISSN 1410 – 0177

	PDF (Peningkatan kelarutan Kuersetin Melalui pembentukan Kompeks Inklusi dengan β-Siklodekstrin) - Published Version Available under License Creative Commons Public Domain Dedication. Download (525Kb)
	Postscript (Peningkatan kelarutan Kuersetin Melalui pembentukan Kompeks Inklusi dengan β-Siklodekstrin) - Published Version Available under License Creative Commons Public Domain Dedication. Download (2103Kb)

Abstract

Quercetin, a chemical cousin of the glycoside rutin from Manihot esculenta Crantz, appears to have several biologically activities. Preformulation studies usually associated with a new potent drug substances, includes solubility. The complexation of quercetin by β-Siklodekstrin indicated an A-type diagram with inclusion complex of 1:1 molar ratio and the stability constant (K) of 403,58 M-1. the complexation enhance solubility 9-fold compared with that of quercetin, howers it was not effective for liquid and oral pharmaceutical applications. Keyword: Quercetin, β-Siklodekstrin, complex of inclusion, solubility

Actions (login required)

View Item