METABOLIC ENGINEERTNG AND BIOSYNTHESIS OF INDOLE ALKALOID IN Catharantus roseus (L) G.DON

Syukur, Sumaryati (2010) METABOLIC ENGINEERTNG AND BIOSYNTHESIS OF INDOLE ALKALOID IN Catharantus roseus (L) G.DON. Jurnal Kimia Andalas, 7 (1). ISSN 0853-8018

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Abstract

Terpenoid indole alkaloids (TIAs) is the most impoftant alkaloid for pharmaceutical interest. Catharanthus roseus (L) G. Don (Apocynaceae) is the commercial source of three such alkaloids,which have pharmaceutical applications and intensively inversigated. Ajrnalicine is used to improve cerebral circulation, and the dirneric alkaloids vinblastine and vincristine are important anticancer drugs. The biosynthesis of tltese alkaloids has been described quite extensivety. fticitor-induced defense responses include the biosynthesis of secondary metabolitls accumulation, gene expression,have been studying for their effect on alkaloid biosynthesis. The effects of environmental ,u.i, as light and abiotik stress on alkaloid accumulation have also been studied.

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