PENGARUH MODIFIKASI KOLOM KROMATOGRAFI DENGAN HEPARIN PADA PEMISAHAN ENANSIOMER SENYAWA ANTIMALARIA CHLOROQUINE

SAFNI, SAFNI (2010) PENGARUH MODIFIKASI KOLOM KROMATOGRAFI DENGAN HEPARIN PADA PEMISAHAN ENANSIOMER SENYAWA ANTIMALARIA CHLOROQUINE. Project Report. LEMBAGA PENELITIAN UNIVERSITAS ANDALAS. (Unpublished)

PDF (PENGARUH MODIFIKASI KOLOM KROMATOGRAFI DENGAN HEPARIN PADA PEMISAHAN ENANSIOMER SENYAWA ANTIMALARIA CHLOROQUINE) - Supplemental Material Available under License Creative Commons Public Domain Dedication. Download (339Kb)

Abstract

The modification effect of chromatographic column with heparin as the stationary phase has been investigated to enantiomeric separation of antimalalial drug chloroquine. Mobite phase conditiorrs such as pH, ionic strer-rgtl.r and organic modifier affected the enantiomeric separation of chloroquine. The optical rotatory (OR) detection of chloroquine enantiomers shows the (+)-enantiomer rvas eluted first. This means that (-)- enantiomer exhibited stronger binding to heparin than (+)-enantiomer. Hydrophobic interaction contributed to the enantiorecognition.

Actions (login required)

View Item