Perbandingan Efek Diuretika Serta Kadar Natrium Dan Kalium Darah Antara Pemberian Ekstrak Etanol Daun Tempuyung (Sonchus arvensis Linn) Dengan Furosemida

Rustam , Erlina and FB, Imelda and EP, Andani (2014) Perbandingan Efek Diuretika Serta Kadar Natrium Dan Kalium Darah Antara Pemberian Ekstrak Etanol Daun Tempuyung (Sonchus arvensis Linn) Dengan Furosemida. Jurnal Sains dan Teknologi Farmasi, 11 (02). ISSN 1410 – 0177

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Abstract

A study on comparative diuretic effect and the sodium and potassium blood levels between the administration the aethanolic extract of tempuyung leaves (Sonchus arvensis Linn) and furosemide on 7 groups of male Wistar rats has been done. Three groups were given various doses of the aethanolic extract of tempuyung leaves (100; 300 and 1000 mg/kgBW respectively), three other groups were given furosemide with the doses of 0.36; 0.72 and 1.14 mg/kgBW respectively and one control group. Results showed that tempuyung extract with doses of 300 mg/kgBW had highest diuretic effect (6.85 mL) in comparison to furosemide 0.72 mg/kg BW (6.575 mL) and control (5,075 mL). The lowest natrium and potassium blood levels of 7.21 and 4.58 ppm respectively were found after administration of 300 mg/kg BW extract compared to 7.60 and 4.29 ppm respectively after the administration of 0.72 mg/kgBW furosemide (these of control were 8.45 ppm and 5.01 ppm for sodium and potassium level respectively). In summary the extract of tempuyung leave at doses 300 mg/kgBW showed a stronger diuretic effect than furosemide at doses 0.72 mg/kgBW. Keywords : Sonchus Arvensi, diuretik

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