PENGGUNAAN MALTODEKSTRIN DARI PATI BERAS (Oryza sativa) SEBAGAI BAHAN PENGIKAT TABLET ASETOSAL

Syofyan, Syofyan and Hakim, Lukman and Arsyadi, Arsyadi (2009) PENGGUNAAN MALTODEKSTRIN DARI PATI BERAS (Oryza sativa) SEBAGAI BAHAN PENGIKAT TABLET ASETOSAL. Jurnal Sains dan Teknologi Farmasi, 14 (1). ISSN 1410 – 0177

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Abstract

Maltodextrin is a starch derivative product generated from partial hydrolysis by α-amylase enzyme with a value of Dekstrose Equivalent (DE) of less than 20. Maltodekstrin was mixed with water to form colloidal liquid when heated and has the ability as a binder. This study aims to find out the comparison of HFR/DT (Hardness, Friability, Disintegration Time) tablets acetosal use from 5-10 DE maltodextrin rice starch as a binder. Acetosal tablet manufacturing is done by direct method. Concentration of maltodextrin used as a binder in each formula is 5%, 15%, 25% and 35%. The results of statistical tests showed F counted (120.33) is greater than the F table (3.11) so it can be concluded that the real difference among the formulas. The results showed increased concentrations of maltodekstrin DE 5-10 can increase the price of HFR/DT acetosal tablets. The HFR/DT highest obtained the formula 4 is 0.4072 Key words : maltodextrin DE 5-10, rice star, binder, HFR/DT

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