Uji Daya Peningkat Penetrasi Virgin Coconut Oil (Vco) Dalam Basis Krim

Lucida , Henny and Salman, Salman and Hervian, M Sukma (2008) Uji Daya Peningkat Penetrasi Virgin Coconut Oil (Vco) Dalam Basis Krim. Jurnal Sains dan Teknologi Farmasi, 13 (1). ISSN 1410 – 0177

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Abstract

A study on the ability of VCO as penetration enhancer in comparison to that of dimethylsulfoxide (DMSO) has been undertaken. Four formulas of cream containing 2 penetrants (promethazine HCl and griseofulvin) and 2 cream bases (containing 40% VCO and 10% DMSO) respectively were made. The profil of penetration was determined by using Franz diffusion cell (vertical type) with the mice’s skin and pH 6.4 phosphate buffer as membrane and medium respectively. Concentration of penetrants was determined spectrophotometically at wavelengths 299,2 nm for promethazine HCl and 291,2 nm for griseofulvin. Results indicated that the penetration profile of both drugs didnot follow either zero order, first order or Higuchi kinetic equations; therefore the rate of penetration couldnot determined. Analysis of data according to Korsmeyer-Peppas equation showed the mechanism of penetration process. The ability of VCO as penetration enhancer was then determined by comparing the Penetration Efficiency (PE) values among formulas. Statistical analysis showed that the ability of VCO as penetration enhancer was far below that of DMSO (p>0,05). Keywords: Virgin Coconut Oil (VCO), dimethylsulfoxide (DMSO), penetration enhancer.

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