Efek Fetotoksisitas Ekstrak Biji Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.)pada Mencit

A, Almahdy and Febrianti, Rika and Djamal, Rusjdi (2008) Efek Fetotoksisitas Ekstrak Biji Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.)pada Mencit. Jurnal Sains dan Teknologi Farmasi, 13 (2). ISSN 1410 – 0177

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Abstract

In order to evaluate Phaleria macrocarpa (Scheff.) Boerl. (Mahkota Dewa) seed extract for possible embryo-fetotoxicity effects and disturbance of postnatal development of pups, female mice were treated on days 6-14 of pregnancy with either the extract (50, 100 and 200 mg/BW) or distilled water (1 ml/mouse), by gastric intubation. Half of the fetus was fixated in red alizarin for skeletal observation and the other half was soaked in Bouin solution. Fetals study suggest of embryo-fetotoxicity on the pups indicating that the seed may be not safe for mice on two higher doses 100 and 200 mg/kg BW. Keywords : fetotoxicity, Phaleria macrocarpa, mice

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