UJI EFEK α-MANGOSTIN TERHADAP KADAR KOLESTEROL TOTAL, TRIGLISERIDA, KOLESTEROL HDL, DAN KOLESTROL LDL DARAH MENCIT PUTIH JANTAN SERTA PENENTUAN LETHAL DOSIS 50 (LD50)

Dachriyanus, Dachriyanus and Katrin, Delpa Oria and Oktarina, Rika and Ernas, Olvia and M. , Suhatri and Mukhtar , Husni (2014) UJI EFEK α-MANGOSTIN TERHADAP KADAR KOLESTEROL TOTAL, TRIGLISERIDA, KOLESTEROL HDL, DAN KOLESTROL LDL DARAH MENCIT PUTIH JANTAN SERTA PENENTUAN LETHAL DOSIS 50 (LD50). Working Paper. Fakultas Farmasi. (Unpublished)

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Abstract

The effect of α-mangostin on total cholesterol levels, trigliserida, HDL, and LDL in blood of white male mice induced by high cholesterol diet consist of palm oil and fat with ratio 5:1 during 7 days was studied. The experiment was divided into six groups those were positive control, negative control, the comparison group with given gemfibrozil 156 mg/kg BW, and 3 various doses (30, 100, and 300 mg/kg BW). The total cholesterol, trigliceride, HDL, and LDL was measured at the day 8 by using the enzymatic methode with spectrophotometer UV-VIS. The result of this observation showed that α-mangostin suspension with doses 30, 100, and 300 mg/kg BW could decreased the total cholesterol, triglyceride, and LDL levels and increased HDL level from the blood of white mice very significant for each doses (P<0,01).

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