Isolasi Senyawa Antimikroba Dari Fraksi Semi Polar Ekstrak Metanol Limbah Kulit Batang Kayu Jati ( Tectona grandis Linn. F )

Alen, Yohannes and Ningrum , Eka Verawati and Rustini, Rustini (2010) Isolasi Senyawa Antimikroba Dari Fraksi Semi Polar Ekstrak Metanol Limbah Kulit Batang Kayu Jati ( Tectona grandis Linn. F ). Jurnal Sains dan Teknologi Farmasi, 9 (2). pp. 55-57. ISSN 1410-0177

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Abstract

An antimicrobial component was successfully isolated from aethyl acetate fraction of Teclona grandis Linn. F (Bark) which was guided by antimicrobial dilution method. Separation and purification were done by chromatographic methods. The active compound namely EV-19-19 (35 mg, m.p 230-232 "C) showed antimicrobial activity against Staphylococcus aureus ATCC 6538 (MIC 100 ppm), Stapylococcus epidermidis ATCC 12228 (MIC 50 ppm), Pseudomonas aeruginosa ATCC 15442 (MIC 50 ppm), Eschericia coli ATCC 8739 (MIC 50 ppm) and Tricophyton mentagrophytes ATCC 543 (MIC 50 ppm). While the compound showed no activity against Candida albicans ATCC 1023. Based on the spectral data (ultraviolet, infrared) and chemical reactions, the compound was identified as steroidal compound. Keywords : Tectona grandis Linn. F., Antimicrobial, Staphylococcus aureus ATCC 6538, Stalphylococcus epidermidis ATCC 12228, Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 8739, Tricophyton mentagrophytes ATCC 543, Candida albicans ATCC 10231l, Metoda dilusi.

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