PLASMA CORTISOL LEVELS IN DYSPEPSIA WITH PSYCHOSOMATIC PATIENTS

murni, arina widya and Julius, Julius and ZUBIR, NASRUL (2014) PLASMA CORTISOL LEVELS IN DYSPEPSIA WITH PSYCHOSOMATIC PATIENTS. Masters thesis, Fakultas kedokteran.

Microsoft Word (Functional Dyspepsia) Restricted to Registered users only Download (161Kb) | Request a copy

Abstract

Background: The interaction between psychological factors with gastrointestinal disorders is believed through brain – gut – axis , including psycho- neuro- immune – endocrinology system, which is direct or indirect could influence on the acid secretion, motility, vascularitation and sensory of pain . Excessive acid secretion may be caused by the stimulation on Hypothalamus-Pituitary-Adrenal axis pathway, starting with the release of Corticotrophins Releasing Hormone (CRH) and the end result is increasing cortisol secretion by adrenal cortex. Objective: To find out the level of plasma cortisol in dyspepsia with psychosomatic patient. Methods : This is an analytic descriptive, cross sectional study with non random consecutive sampling. After diagnosis of dyspepsia, depression, anxiety and both of depression – anxiety , all subjects were examine gastroscopy and plasma cortisol in the morning and evening . Results: There were 40 patients with dyspepsia and psychosomatic disorders and 10 patients with dyspepsia without psychosomatic symptom as control group. Range of age was 20 – 40 years old, There was an increased cortisol level in the morning in sample with mean 322,33 ± 166,92 nmol/L compared to normal group 188,84 ± 103,14 nmol/L, and the difference was statistically significant (p < 0,05 ). Level cortisol in the evening was higher in psychosomatic group with mean 163,09 ± SD 130,29 nmol/L comparing to normal group 112,69 ± 86,46, nmol/L but the differences was not significant. Depression group had a significant higher morning cortisol with mean 328,92 ± 172,98 nmol/L comparing to normal 188,84 ± 103,14 nmol /L, (p< 0,05 ). There was no significant difference in cortisol level in anxiety and both of depression – anxiety group comparing to normal. Conclusion: The level of morning plasma cortisol in dyspepsia with psychosomatic patients ( especially depression) was significantly higher than in dyspepsia without psychosomatic . Key word : dyspepsia, cortisol plasma, psychosomatic disorders

Actions (login required)

View Item