SINUS HISTIOSITOSIS DENGAN LIMFADENOPATI MASSIF

Hilbertina, roza and Nizar, RZ (2010) SINUS HISTIOSITOSIS DENGAN LIMFADENOPATI MASSIF. SINUS HISTIOSITOSIS DENGAN LIMFADENOPATI MASSIF . (Unpublished)

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Abstract

Sinus Histiocytosis with Massive Lymphadenopathy (SHML), also known as Rosai Dorfman Disease (RDD), is a rare benign idiopathic proliferative disease of phagocytic histiocytes. Approximately 80% of patients presents with painless massive cervical lymphadenopathy. Sinus histiocytosis is characterized histologically by nodal sinus dilatation with nonneoplastic proliferation of histiocytes. These histiocytes typically demonstrate a foamy or vacuolated eosinophilic cytoplasm and characteristically contain small, mature lymphocytes, a condition called lymphocytophagocytosis or emperipoleis. The hystiocytes of SHML are immunoreactive with S-100 protein. Many patients experience spontaneously regressing courses, but some patients will have disease present in more extensive. We report a first case of SHML in our laboratory.

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