PERBEDAAN SENSITIVITAS KUMANPSEUDOMONAS AERUGINOSA PENYEBAB INFEKSI NOSOKOMIAL TERHADAP ANTIBIOTIKA GENERIK DAN ANTIBIOTIKA PATEN

PUTRI, AYU ANDRIAN (2014) PERBEDAAN SENSITIVITAS KUMANPSEUDOMONAS AERUGINOSA PENYEBAB INFEKSI NOSOKOMIAL TERHADAP ANTIBIOTIKA GENERIK DAN ANTIBIOTIKA PATEN. Other thesis, ANDALAS UNIVERSITY.

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Abstract

ABSTRACT SENSITIVITY DIFFERENCES OF PSEUDOMONAS AERUGINOSA THAT CAUSED NOSOCOMIAL INFECTION TOWARDS GENERIC AND BRANDED NAME ANTIBIOTICS BY AYU ANDRIAN PUTRI 1010312079 Nosocomial infections are infections acquired in hospitals, occurred after 72 hours of treatment in hospitalized patients and could also in patients treated for longer than the incubation period of a disease. According to research, one of the causative organism of nosocomial infection is Pseudomonas aeruginosa. The high cost of health care is actually derived from the drug can be suppressed significantly if patients use generics. But, there has been a wrong perception among the public that generic drugs are the properties of two classes of drugs less than branded name medicine. Some of studies proved that the effectiveness of generic drugs and patent are the same. The goal is to see and compare the germfree zone of Pseudomonas aeruginosa causing nosocomial infection after given the antibiotics generic and branded name. The experiment was conducted from June 2013 to December 2013 at the Microbiology Laboratory of the Andalas University. The experiment used 24 sample of P. aeruginosa from nosocomial infection patient in RSUP M. Djamil Padang that determinded by simple random sampling formula and used Kirby- Bauer diffusion method then counted the free zone germ towards 4 antibiotics generic and branded name. From the results founded that generic and branded name of amoxicillin and erythromycin did not have results of germ-free zone, the germ-free zone of 3 sample that tested with generic kloramfenikol is bigger than the branded name and the less are the other way and the germ-free zone of 8 sample that tested with generic siprofloksasin is bigger than the branded name and the less are the other way. After doing statistical analysis using SPSS 11.5 through the independent T-test showed that there was no significant difference between the sensitivity of Pseudomonas aeruginosa causes of nosocomial infections between generic and branded name of chloramphenicol and ciprofloxacin. Whereas about the resistance in amoxicillin dan eritromisin assumed because the influenced by irrasional antibiotics given in hospital and the prescription from the doctor. Key words: Pseudomonas aeruginosa, nosocomial infection, sensitivity,

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