FIRDAUS, VASHTI RESTI PUTRI
(2014)
HUBUNGAN GRADING HISTOPATOLOGI DAN INFILTRASI
LIMFOVASKULAR DENGAN SUBTIPE MOLEKULER PADA KANKER
PAYUDARA INVASIF DI BAGIAN BEDAH RSUP DR. M. DJAMIL PADANG.
Other thesis, ANDALAS UNIVERSITY.
Abstract
ABSTRACT
Firdaus, Vashti. 2014. Association between Histopathology Grading and
Lymphovascular Infiltration with Molecular Subtypes of Invasive Breast Cancer
at Surgery Department, Dr. M. Djamil Hospital Padang . Undergraduate Thesis,
Faculty of Medicine, Andalas University.
Supervisor : (I) dr. Aswiyanti Asri, M.Si.Med, SpPA, (II) dr. Daan Khambri, SpB
(K) Onk, M. Kes.
Keywords : histopathology grading, lymphovascular infiltration, molecular
subtypes, invasive breast cancer.
Breast cancer is the most common type of cancer found among women
worldwide. In Indonesia, breast cancer is also the most common cancer
suffered by Indonesian women. Breast cancer symptoms are often not recognized
or clearly perceived by the patient, so it makes most of patients come to doctor in
late stage. It will certainly affect the patient's prognosis and cure rate.
Breast cancer is divided into in situ breast cancer and invasive breast
cancer. In situ breast cancer is cancer that has not penetrated the basement
membrane, whereas invasive breast cancer is cancer that has penetrated the
basement membrane to enter the stroma.
Many factors affect the prognosis of breast cancer , including in situ breast
cancer / invasive breast cancer, metastatic to the lymph/other organs, tumor size,
histopathology grading, estrogen and progesterone receptors, HER2, and
lymphovascular infiltration .
The design study was observational and analytic , ie to determine the
association between histopathology grading and lymphovascular infiltration with
molecular subtypes of invasive breast cancer at surgery departement, Dr . M.
Djamil hospital, Padang period January 1, 2010 - December 31, 2013. In this
study obtained 424 cases of invasive breast cancer, with only 66 cases that could
be analyzed.
From the result of this study showed that most invasive breast cancer is on
the luminal B molecular subtype and triple negative moleculer subtype, most of it
in grade II, and most of it has occured lymphovascular infiltration. From the
calculation of the correlation coefficient, which is to determine the association
between histopathology grading and molecular subtypes in invasive breast cancer
found a significant correlation and association between lymphovascular
infiltration and molecular subtypes in invasive breast cancer also found a
significant correlation.
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