ARIANTO, ADI ARIANTO
(2014)
HUBUNGAN HIPERGLIKEMIA DENGAN KADAR VASCULAR ENDOTHELIAL GROWTH FACTOR
(VEGF) PADA PENDERITA DIABETES
MELITUS (DM) TIPE 2.
Other thesis, ANDALAS UNIVERSITY.
Abstract
ABSTRACT
RELATIONSHIP OF HYPERGLYCEMIA ON VEGF LEVELS
IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.
Background: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormal insulin secretion, insulin action function , or both. The mechanism of tissue damage in diabetes mellitus through four main pathways that polyol pathway, formation of AGEs (Advanced glycation end products ) , increased activation of PKC ( protein kinase C) via an increase in DAG (diacyl glycerol), and hexosamine pathway. Hyperglycemia causes increased intracellular synthesis of DAG which cause the expression of PKC in cells also increased which in turn would alter the expression of a wide variety of genes that overall damage blood vessels . Increased aktivikasi PKC resulted in increased VEGF (vascular endothelial growth factor). Increased VEGF will result in increased vascular permeability and angiogenesis .
Objective: This study aimed to determine the relationship of hyperglycemia on VEGF levels in patients with type 2 diabetes mellitus.
Research methods : This is cross-sectional study design. The number of samples are 70 people . Group of 35 people with type 2 diabetes and 35 non- DM as a control group. Examination of the blood glucose levels and HbA1c levels enzymatic methods with techniques hemoglobin variant testing system. The level of HbA1C indicate uncontrolled DM. The level of VEGF by Enzyme-linked Immunosorbent Assay (ELISA). Test data analysis using t - test and correlation regression .
Results: The mean levels of VEGF in type 2 DM group was 398.35 + 229.62 pg / ml. In the non-DM group 274.99 + 197.62 pg / ml. HbA1C levels in patients with type 2 diabetes showed 8.87 + 1.48%. Test results of t-test analysis to determine differences in the mean levels of VEGF in the group of patients with type 2 diabetes with a mean concentration of VEGF in non-DM group obtained the value of p = 0.019 (p ˂ 0.05). These results indicate that there are significant differences between the levels of VEGF in patients with type 2 DM group with VEGF levels in the non-DM group. Results of Pearson test analysis to determine the relationship of fasting blood sugar levels of VEGF levels obtained with p = 0.024 (p ˂ 0.05). These results indicate that there is a significant relationship between fasting blood sugar levels with increased levels of VEGF..
Conclusion : The mean levels of VEGF in patients with type 2 diabetes is higher than average levels of VEGF in non-DM. There is a significant difference between the levels of VEGF in patients with type 2 diabetes and non-diabetes. There is a relationship of fasting blood sugar levels increase with increased levels of VEGF in patients with type 2 diabetes mellitus.
Keywords : Type 2 diabetes mellitus, hyperglycemia, reactive oxygen species, VEGF
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