Aldi, Yufri and Yuliandra , Yori and Nasrul, Ellyza and Yanwirasti, Yanwirasti and Handayani , Dian and Bakhtiar, Amri
(2015)
Decreased Interleukin-4 Level of Type I Hypersensitive Mice Using Scopoloetin Isolated from Noni Fruit (Morinda citrifolia L.).
Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6
(4).
pp. 1823-1829.
ISSN 0975-8585
Abstract
An in vivo study of the activity of scopoletin isolated from noni fruit (Morinda citrifolia L.) on the level
of interleukin-4 (IL-4) in type I hypersensitive male Swiss-Webster mice has been carried out. Scopoletin was
isolated from dried noni powder by soxhletation method using dichloromethane, separated by column
chromatography using silica gel as stationary phase and n-hexane-ethyl acetate (1:4) as mobile phase, then
purified by column chromatography using Sephadex LH20 as stationary phase and methanol as mobile phase.
Type I hypersensitive male mice were obtained by ovalbumin sensitization. Animal model were divided into 5
groups: negative control group, positive control group, and scopoletin-treated group (1; 3; and 10 mg/kg). The
results showed that scopoletin at doses of 1, 3 and 10 mg/kg decreased the level o f IL-4 of type I hypersensitive mice significantly (p <0.01). The scopoletin at the dose of 10 mg/kg decreased the serum level of IL-4 to the normal level.
Keywords: noni fruit, morinda citrifolia, scopoletin, type I hypersensitivity, interleukin-4
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