Yufri, Aldi and Rasyadi, Yahdian and Handayani , Dian
(2014)
Aktivitas Imunomodulator dari Ekstrak Etanol Meniran
(Phyllanthus niruri Linn.) terhadap Ayam Broiler
Immunomodulatory Activity of Meniran Extracts (Phyllanthus niruri Linn.) on
Broiler Chickens.
Jurnal Sains Farmasi & Klinis, 1
(1).
pp. 20-26.
ISSN 2407-7062
Abstract
ABSTRACT: Broilers chickens are highly susceptible to many diseases caused
by bacteria and viruses. Therefore to solve these problem we can use alternative
medicine by administration of immunostimulatory compounds that can prevent
disease in broiler chickens. One of the plants that can enhance the immune system
is meniran. The study effect of immunomodulatory test from ethanol extract of
meniran herbs (Phyllanthus niruri Linn.) has been conducted in broiler chickens
with carbon clearance method. The study of extract administered orally with
dose of 10; 30; 100; 300 mg/kg BW and a solution of 0.5% NaCMC as negative
control also suspension Stimuno® forte 13.5 mg/kg BW as positive control for
6 days. The data of phagocytosis index was analyzed statisticaly with two way
ANOVA followed with Duncan’s test. The increasing of phagocytosis index with
carbon clearance method showed the effect from each dose with negative control
was significant (P<0,05). The highest phagocytic index obtained from a dose of
300 mg / kg BW. The data’s of increased relative spleen weight and an increased
of blood limfosit cell was analyzed statisticaly with one way ANOVA followed
with Duncan’s test. Increased relative spleen weight and an increased of blood
limfosit cell showed effect from each dose to negative control was significant
(P<0,05). The results indicated that the ethanolic extract of meniran was active
as immunostimulant for broiler chickens.
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