Aldi, Yufri and Novelin , Frisky and Handayani , Dian
(2015)
AKTIVITAS BEBERAPA SUBFRAKSI HERBA MENIRAN (Phyllanthusniruri Linn.)TERHADAP AKTIVITAS DAN KAPASITAS FAGOSITOSIS MAKROFAG.
Scientia - Jurnal Farmasi dan Kesehatan, 5
(2).
ISSN 2087-5045
Abstract
Study about the activity of some subfraction of ethyl acetate extract of herba meniran have been done. The parameters determined were the phagocytosis activity and capacity of peritoneal macrophages of male mice (Mus musculus) in vivoinduced by Staphylococcus aureus. Subfraction of 1,2,3,4,5,6,7, and 8 were tested at a dose of 100 mg/kg and 1% Tween 80 was used as a control, all
were given orally for 7 days. Activity and capacity of phagocytosis were calculated on the 8th day after
the number of cells blood leukocytes counted from tail blood and suspension of Staphylococcus aureus
injected intraperitoneally. Test result showed that subfraction of 1,2,3,4,5,6,7, and 8 at dose 100
mg/kg bb did not affect the number of leukocyte. Whereas phagocytosis activity increased significantly
(P<0.05), highest activity showed by subfraction 4, which was 96% compared to 62.58% control, and
the capacity of phagocytosis increased significantly (P<0.01), highest capacity was showed by the
subfraction 4 which was 109.50% compared to control of 77.83%.
Keywords : subfraction, herba meniran, activity and capacity of phagocytosis
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