Yuliandra, Yori and Armenia, Armenia and Salasa, Annisa Nur and Ismed, Friardi
(2015)
Uji Toksisitas Subkronis Ekstrak Etanol Tali Putri (Cassytha filiformis L.) terhadap Fungsi Ginjal Tikus.
Jurnal Sains Farmasi & Klinis, 2
(1).
pp. 54-59.
ISSN 2407-7062
Abstract
Sub-chronic toxicity test of the deffated ethanolic extract of Cassytha filiformis L. on the renal function of rat has been carried out. A number of 16 male rats aged 2-3 months, weighing ±250 g were used as experimental animals. The rats were divided into 4 groups which consisted of 1 control group and 3 extract-treated groups given 1.25, 2.5, and 5 mg/kg extract administrated intraperitoneally once a day for 14 days. The creatinine clearance, renal function, and the ratio of renal were calculated and analyzed by two-way ANOVA. The study showed that the creatinine clearance and renal function decreased significantly during treatment (p<0.05). The kidney weight ratio of groups treated with extract, especially with greater doses, showed a very significant increase as compared with control (p<0,01). These indicated that the ethanolic extract of C. filiformis on the doses of 1.25 – 5 mg/kg might decrease the renal function, althought it seemed to be relatively safe when used for 14 days.
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