Teratogenic Assessment of Phaleria macrocarpa (Scheff.) Boerl. Extract in Ovo

A, Almahdy and Wahyuni, Sri and Djamal, Rusjdi (2008) Teratogenic Assessment of Phaleria macrocarpa (Scheff.) Boerl. Extract in Ovo. Jurnal Sains dan Teknologi Farmasi, 13 (2). pp. 86-88. ISSN 1410-0177

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Abstract

Teratogenic activity of the aethanolic extract of Phaleria macrocarpa (mahkota dewa) fruit was observedby in ovo method on quail eggs. The extract was given by direct injection to the yolk at the 4th, 6th ,8 th and the 1O th day of incubating with variefy of doses of 25, 50, 100 and 200 mg/kgEw respectively. The experiment was conducted under aceptic conditions. The eggs were incubated at 38-39o C for 14 days. In day 15 th embryos were taken and then were immersed in red alizarin and the rest in Bouins solution. Results showed that the extract affected the weight of eggs and embryos. Injection of extract at 4 th and 6 th day caused lethal effects, wich was found in all variaty of dosage. The injection at day 8 th for all variety of doses, only several organs growth completely. While the injection at day 10 th with doses of 25,50 and 100 mg/kgEW respectively showed dislocation of the intestines. At dosse 200 mg/kgEW dislocation of intestines and incomplete formation of feathers were observed. Key words : Phaleriatna crocarpa, teratogenic, in- ovo

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