A STUDY OF ANTICANCER OF METHANOLIC EXTRACT FRACTIONS OF SUMATRAN Ficus pruniformis, Ficus cunia, Ficus variegate,and Ficus lepicarpa ON MICE BY BONE MARROW METHOD

Adnan, Adek Zambrud (2010) A STUDY OF ANTICANCER OF METHANOLIC EXTRACT FRACTIONS OF SUMATRAN Ficus pruniformis, Ficus cunia, Ficus variegate,and Ficus lepicarpa ON MICE BY BONE MARROW METHOD. Project Report. Lembaga Penelitian Universitas Andalas. (Unpublished)

PDF (A STUDY OF ANTICANCER OF METHANOLIC EXTRACT FRACTIONS OF SUMATRAN Ficus pruniformis, Ficus cunia, Ficus variegate,and Ficus lepicarpa ON MICE BY BONE MARROW METHOD) - Supplemental Material Available under License Creative Commons Public Domain Dedication. Download (652Kb)

Abstract

During a phyochemical survey along Anai river in Anai Valley, padangpanjang West Sumatra four trees locally known as "Loloi", "Buku'", "First "ikan-ikan", Second ikan- ikan" were found and their barks, leaves or fruifs gave e (+) alkaloid or flavonoid test. Those plants were identified by Herbarium of Deprtmenf of Biology, Andalas University as Ficus cunia Buch-Ham (Moraceae), Ficus variegata Bl, Ficur lepicarpa Bl, and Ficus pruniformis Bl. (2, 3, 4, 5, 6, 7, 8). The anticancer test were conducted based on the formation of micronuclei cells induced by cyclophosphamide in bone marrow of mice hind leg The tested compound were hexane, chloroform and ethyl acetate fraction from alkaloid extract aad hexane, neutral chloroform, and basic chloroform fraction from alkaloid extract scheme. The tested compound were administered orally for 7 consecutive days with dose af 300 mg/kg. body weight to white male mice. The experimental animals were then treated intraperitoneally with cyclophpsphamide at a dose of 50 mg/kg body weight. The results indicated that the number of micronucler cells affected by the all tested compound in mice were smaller then of control group {55.55% }" The strong decreasing effect were showed by ethyl acetate fraction of flavonoid of fruit of Ficus pruniformis (22,89%) and neutral chloroform fraction of alkaloid of leaves of Ficus lepicarpa B1 (25,44 %}.

Actions (login required)

View Item