A Comparative Dissolution Test between Generic and Branded Name of Furosemide Tablets

Lucida, Henny and Erizal, Erizal and Rahmi, Sri (2014) A Comparative Dissolution Test between Generic and Branded Name of Furosemide Tablets. Jurnal Sains dan Teknologi Farmasi, 11 (02). ISSN 1410 – 0177

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Abstract

A study on comparative dissolution rates betwen two generic tablets and two branded name of furosemide tablets has been undertaken. Method applied was paddle method as required by FI IV, and furosemide concentration was measured spectrophotometrically at maximum wavelength of 277.5 nm. The dissolution profiles were drawn from the plot between percentage of furosemide dissolved versus time, and linearized according to Langenbucher equation. Results showed that at 5 th minute of dissolution, the dissolution rates between generic tablet A1 and brand name tablets B1 and B2 were not significantly different but there was a significant difference between tablets A1, B1, B2 and generic tablet A2. At 10th minute, the dissolution rates between brand name tablets (B1 and B2) were not significantly different, but there was a significant difference between brand name tablets (B1 and B2) and generic tablets (A1 and A2). At 15th minute, all tablets showed a significant difference in dissolution rates. Keywords: comparative dissolution, furosemide tablet, dissolusion profile

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