Pengaruh Asam Borat Terhadap Ovarium Mencit Putih (Mus musculus L)

marusin , Netty and munir, warnety and suryani, Nila (2010) Pengaruh Asam Borat Terhadap Ovarium Mencit Putih (Mus musculus L). Jurnal Sains dan Teknologi Farmasi, 9 (2). ISSN 1410 – 0177

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Abstract

A study on the effect of the horic acid on the ovary of mice (Mus musculus L) has been done at the laboratory Embriology and Histology, faculty of Matematics and science Andalas University. A complete randomized design (CRD) with four treatments and six replications was used in this study. The dose of 0, 1500, 3000 and 4500 ppm of boric acid were given respectively to each group of mice and the ovary diametere and its histological structured were measured. Result showed that there was a decrease in the diameter of the mice ovary with an increase in dose. Histologically, these ovary showed that the follicle growth was stopped at the secondary level at the dose of 3000 and 4500 ppm of boric acid doses. Furthermore, the number of primary and secondary follicle decreased, the diameter of secondary follicle also decreased but the diameter of primary follicle were constant by increasing the dose. Keyword: Boric acid, Ovary, primary follicle, secondary follicle

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