Teratogenic Assessment of Phaleria macrocarpa (Scheff.) Boerl. Extract In Ovo

A, Almahdy and wahyuni, Sri and Djamal, Rusdji (2008) Teratogenic Assessment of Phaleria macrocarpa (Scheff.) Boerl. Extract In Ovo. Jurnal Sains dan Teknologi Farmasi, 13 (2). ISSN 1410 – 0177

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Abstract

Teratogenic activitie of the nethanolic extract of Phaleria macrocarpa (mahkota dewa) fruit was observed by in ovo method on quail eggs. The extract was given by direct injection to the yolk at the 4 th, 6 th, 8 th and the 10th day of incubating with variety of doses 25, 50, 100 and 200 mg/kg EW respectively. The experiment was conducted under aceptic conditions. The eggs were incubated at 38-39o C for 14 days. In day 15th embryos were taken and then were immersed in red alizarin and the rest in bouins solution. Keyword: Phaleria macrocarpa, teratogenic, in-ovo

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